哪个蛋白质严格符合以下标准？ 前体多肽的长度为210到230个氨基酸残基。 编码该蛋白质的基因跨越3...

Pinpointing the protein

I’m mapping out a protein that fits a specific criterion: a 210-230 amino acid precursor, a 32 kb gene on the X chromosome, a 23 amino acid signal peptide, and a role in cell adhesion and nervous system health.

Weighing potential candidates

Considering proteins like myelin oligodendrocyte glycoprotein (MOG), Arylsulfatase A (ASA), and others. Need more details to evaluate their alignment with criteria.

Listing potential proteins

I'm pulling together various proteins like Neuroligin 4 X (NLGN4X), Neuroligin 3, and CD99 (MIC2). Each has specific locations and characteristics, but more details are needed to confirm alignment.

Identifying potential proteins

Considering KAL1 for Kallmann syndrome as a candidate, though it’s not a typical adhesion molecule and is much larger than the 210-230 amino acids range.

Narrowing down the options

I’m noting neuroligin genes NLGN4X and NLGN4, though NLGN4X has 818 amino acids, exceeding the 210 limit. Custom cell adhesion molecules like SynCAM might be more fitting.

Mapping the options

Considering MYH9, which fits the gestational age, location, and cell types. It engages with nucleolar nitrosylation and cell cycle processes. This seems promising.

Investigating CD99 characteristics

I'm digging into CD99, noting its potential precursor form aligns with 210-230 amino acids. The search continues for longer isoforms or additional details to ensure it fits the specific criteria.

Spotting potential proteins

I’m noting retinal disease-related genes like RP2 and RPGR. Not cell adhesion molecules, but let’s see if they’re relevant. Progressing through options, I’m examining their involvement.

Evaluating cellular relevance

Hmm, I’m thinking about cell adhesion molecules in the Xp22 region, crucial for specific nervous system health. Options like GPR143 and PHEX are intriguing, despite their large sizes.

Looking for more clues

Now I'm examining genes like PCDH19 for neural cell adhesion in the retina or spinal cord. Interestingly, CLIC2 emerged as a chloride intracellular channel, stray from adhesion molecules.

Gathering info

I'm examining its 210-230 amino acids, 32 kb gene, and Xp22 location. Protocadherin stands out for neural adhesion, despite recent findings showing amelogenin's diverse isoforms in this region.

Taking a closer look

Interestingly, myelin P2, Netrin G, and neuroligin seem relevant but don’t fit the 210-230 amino acid range. Reassessing to support decision-making.

Evaluating cerebellin 4

Given its 193 amino acids and intriguing adhesion role, cerebellin 4 is under consideration. Still, checking its Xp22 location in humans is crucial. Progressing through these aspects.

Weighing cerebellin 4

OK, let’s see. Its Xp15.1 location and 202 amino acids don't quite fit the Xp22 and 210-230 amino acid range. Still exploring other options, but it’s worth noting.

Evaluating cerebellin 3's position

Cerebellin 3's Xp26 spot and 227 amino acids seem too far from Xp22. The 32 kb gene size also throws me off—I'm thinking through these gaps.

Examining cerebellin 3's relevance

Cerebellin 3 links to cerebellar synapse formation, fitting the need for a crucial nervous system protein. Xp22 might be its resting place. Progressing here is key.

Wondering about cerebellin 4

Hm, I’m thinking cerebellin 4's 225 amino acids and Xp22 gene location hit the mark. The 32 kb gene size aligns too. This makes me think it’s worth considering.

Focusing on cerebellin 4

I've pinpointed cerebellin 4's 225 amino acids and Xp22 location, confirming its fittingness for the query. Now, I’m piecing together other details to complete the scope.

Weighing different routes

Piecing together details on adhesion molecules like GPM6A, I’m matching them with Xp22.2 and aiming for the 210-230 amino acid range. Progress is steady and evolving.

Weighing options

I'm mapping out GPM6B's Xp22 location and 278 amino acids, but it seems too large. Others like "protocadherin gamma cluster" and "NLGN4X" also seem too big.

Pulling together

Examining SynCAM1 and Nectin-like molecules, mapping their chromosome locations and lengths to fit the criteria of 210-230 amino acids and Xp22. Progress is steady.

Weighing possibilities

Now I'm looking into genes like PANX3 and IL1RAPL1. While they aid in cell adhesion or synapse formation, they tend to be larger than the 210-230 amino acid range.

Assessing possibilities

Considering PRRG1's vitamin K dependency and the Sushi repeat-containing SRPX2. Also, Synaptophysin and Synaptoporin stand out, but their Xp11 locations don't align with Xp22.

Piecing it together

OK, let me see: L1CAM is out due to its 1257 aa size on Xq28. Genes like Foxp3, USP27X, and ECRO1 don't fit the given criteria.

Evaluating options

I evaluated genes including OTUD5, Cenpj, and spacemarking genes. Tenomodulin seemed promising at 317 aa, aligning well with the criteria of 210-230 amino acids.

Piecing together

I reviewed VCAM, ICAM, and NCAM, but their Xp22 locations don't fit. Interestingly, HNK-1 is a carbohydrate epitope, excluding it from protein consideration.

Evaluating continuity

I examined genes like CNTN2, NRCAM, and OPALIN. Their locations outside Xp22 and atypical sizes led me to consider Neurexophilins and SALL4 as potential matches for the criteria.

Cross-referencing genes

I’m thinking through HNK-1 and RS1, which is notable for its Xp22.2 positioning and involvement in retinal cell adhesion. This makes me think RS1 might be the right answer.

Confirming gene details

RS1 gene on Xp22.2 fits perfectly: 224 amino acids including signal peptide, crucial for retinal health. This aligns well with the specified precursor polypeptide length.

Reasoned for 1m 14s