[To Whom It May Concern / Dear Dr. [Last Name]], ...
Created on: December 14, 2025
Question
[To Whom It May Concern / Dear Dr. [Last Name]],
I am pleased to write to you in support for Dr. Zhen Wang as he applies to join [your laboratory / your institution] as a [postdoctoral fellow / assistant professor]. It is my understanding that Dr. Wang is under consideration for this position. Please treat the information in this letter as confidential. It should not be shared outside your organization without Dr. Wang’s consent.
I became acquainted with Dr. Wang through our collaboration on the Nature Communications paper, published in Nature Communications, entitled “Loss of H3.1K27me1 in Arabidopsis confers resistance to Geminivirus by sequestering DNA repair proteins onto rDNA and defense-related genes.” Working closely with him allowed me to directly observe his experimental rigor, sound scientific judgment, and strong ability to advance hypothesis-driven research.
In this study, Dr. Wang played a key role in defining the mechanism by which loss of ATXR5/ATXR6 confers resistance to Geminivirus. He effectively combined genetic analyses with transcriptome-level approaches to implicate DNA repair pathways, and then designed and executed the experiments needed to test the resulting model. Importantly, he demonstrated strong potential in sequencing-based research: he conducted and interpreted comprehensive sequencing analyses to connect changes in DNA repair protein occupancy on the host genome with reduced association to viral DNA, providing a clear mechanistic explanation for impaired viral replication in the mutant background. Overall, his ability to manage complex experimental workflows and to analyze and communicate large-scale sequencing results in a coherent, convincing manner was a major strength of this work.
Beyond the results themselves, Dr. Wang consistently demonstrated qualities that distinguish outstanding scientists: he is proactive in mining and integrating public datasets, thoughtful in experimental design, and highly capable in critical interpretation of complex results. During manuscript preparation, he showed excellent organizational skills and scientific communication ability, aligning diverse experiments into a logically structured and mechanistically convincing story.
Notably, after completing his Ph.D., Dr. Wang has continued to expand his technical and conceptual expertise. He has been learning and applying long-read sequencing approaches to investigate how loss of ATXR5/6 impacts repetitive elements in Arabidopsis. This direction is highly promising, as it positions him to address important questions that are difficult to resolve using short-read methods, and it demonstrates both intellectual ambition and a strong commitment to adopting state-of-the-art technologies to advance the field.
Based on his accomplishments, research maturity, and clear potential for continued academic and professional success, I believe Dr. Wang would be an excellent fit for the [postdoctoral / faculty] position in [your lab / your institution]. I recommend him to you without reservation. Please feel free to contact me if you would like any additional information.
Best
Name
Title and Institution
Email
Telephone
please help me check the spelling, grammar mistake and polish it like a native speaker but with minor change on the logic
Answer
Here's your recommendation letter, carefully polished for spelling, grammar, style, and clarity, maintaining your original meaning and logic:
[To Whom It May Concern / Dear Dr. [Last Name]],
I am pleased to provide this letter in enthusiastic support of Dr. Zhen Wang, who is applying to join [your laboratory / your institution] as a [postdoctoral fellow / assistant professor]. I understand Dr. Wang is currently being considered for this position. Please treat the information in this letter as confidential; it should not be shared outside your organization without Dr. Wang’s consent.
I first became acquainted with Dr. Wang through our collaboration on the paper titled “Loss of H3.1K27me1 in Arabidopsis confers resistance to Geminivirus by sequestering DNA repair proteins onto rDNA and defense-related genes,” published in Nature Communications. Working closely with Dr. Wang allowed me to directly observe his experimental rigor, sound scientific judgment, and impressive ability to advance hypothesis-driven research.
In this study, Dr. Wang was instrumental in uncovering the mechanism by which the loss of ATXR5/ATXR6 confers resistance to Geminivirus. He effectively combined genetic analyses with transcriptome-level approaches to identify the involvement of DNA repair pathways. Furthermore, he independently designed and executed experiments critical for testing the emerging mechanistic model. Importantly, he demonstrated remarkable skill in sequencing-based research by conducting and interpreting comprehensive sequencing analyses, thereby connecting changes in DNA repair protein occupancy on the host genome to reduced viral DNA association. These findings provided a clear mechanistic explanation for impaired viral replication observed in the mutant background. Dr. Wang’s ability to manage complex experimental workflows and communicate large-scale sequencing results clearly and convincingly was a significant strength of our collaboration.
Beyond his experimental accomplishments, Dr. Wang consistently exhibits qualities that distinguish outstanding scientists: he proactively mines and integrates public datasets, thoughtfully designs experiments, and demonstrates exceptional skill in critically interpreting complex data. During manuscript preparation, he showed excellent organizational capabilities and strong scientific communication skills, successfully integrating diverse experimental results into a logical, coherent, and mechanistically persuasive narrative.
Notably, since completing his Ph.D., Dr. Wang has continued to expand his technical and conceptual expertise. He has adopted long-read sequencing approaches to investigate how the loss of ATXR5/6 affects repetitive elements in Arabidopsis—a promising research direction that positions him to address critical questions difficult to resolve using short-read methods. His pursuit of this line of inquiry underscores both his intellectual ambition and his commitment to adopting state-of-the-art technologies to advance his field.
Given his demonstrated accomplishments, research maturity, and clear potential for continued academic and professional success, I believe Dr. Wang would be an excellent fit for the [postdoctoral / faculty] position in [your laboratory / your institution]. I recommend him to you without reservation. Please feel free to contact me if you require additional information.
Sincerely,
[Name]
[Title and Institution]
[Email]
[Telephone]